4. Tetracyclic derivatives
Two classes of drugs feature a sequence of 4 fused cyclohexanoperhydroanthracene rings. Structurally, tetracycline antibiotics have a single aromatic ring, a dimethylamine function and a substituted or unsubstituted amide function. In contrast, anthracyclines with anticancer properties share 2 aromatic rings and 1 aminosugar-type substituent (figure 7 ).
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Tetracyclic derivatives
Macrocyclic derivatives
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