1. What is acute toxicity?
Acute toxicity is a dramatic systemic toxic action caused by a single oral, dermal or inhalation exposure to a chemical substance. This action severely alters the functioning of the exposed organism, and can lead to death within a very short latency period.
The degree of severity always depends on the dose received.
Acute toxicity manifests itself in a variety of ways. They are the consequence of the blocking of vital functions, or the secondary effects of a localized action, for example :
hydrocyanic acid (HCN) blocks the cellular respiratory chain (Krebs cycle) and stops the functioning of all affected cells, which die of anoxia;
carbon monoxide (CO) binds to hemoglobin to form carboxyhemoglobin, which prevents the exchange of oxygen in the blood;...
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What is acute toxicity?
How is acute toxicity expressed?
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Bibliography
A. Lombard et al (2024), part 2 pp 153-281, Techno-economic evaluation of products at the initial stage of development, ISTE éditions Ltd London.
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