7. Human test: Standard Test Method for Human Repeat Insult Patch Testing(HRIPT), ASTM D6355
This test was developed in the USA and standardized by ASTM to assess the sensitizing potential of a cosmetic preparation or medical device intended to remain in contact with the body.
The test principle is the same as for animal testing:
induction: study material is applied at relatively low or non-irritating doses to the volunteer's back or arm for three weeks;
two-week latency period;
Triggering: a single application of a non-irritating dose is made for 48 hours;
skin reaction scoring: erythema and edema are examined and scored.
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Human test: Standard Test Method for Human Repeat Insult Patch Testing(HRIPT), ASTM D6355
Photoallergy
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www.oecd.org OECD Guidelines for the Testing of Chemicals: these are a set of internationally-agreed test methods used by governments, industry and independent laboratories to determine the safety of chemicals and formulations, including pesticides and industrial chemicals. They cover tests on the physico-chemical properties of substances, their effects on human...
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