Practical sheet | REF: FIC1175 V1

Systemic toxicity: kidneys, primary target organs

Author: Alain LOMBARD

Publication date: May 10, 2025 | Lire en français

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1.  What are the characteristics of kidneys?

1.1 Kidney composition

The kidneys are bean-shaped and about 10 cm x 5 cm in size.

A kidney is made up of richly vascularized filtration units, the nephrons, which are composed of a renal capsule (blood glomerulus enveloped in Bowman's capsule). This is extended by a long, contoured tube, comprising four portions with different functions:

  • proximal tube;

  • the U-shaped loop of Henlé ;

  • distal tube;

  • Bellini's collecting tube, which evacuates urine.

An adult human kidney contains around 1 million nephrons.

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What are the characteristics of kidneys?