Overview
ABSTRACT
Collagen-based biomaterials are commonly used for wound healing and tissue engineering. This article recalls the biological function of collagen and its highly hierarchical structure. Procedures for extracting and processing natural collagen are described, and healthcare applications of collagen-based scaffolds are reviewed. The article then looks at synthetic collagen-mimetic peptides. An example of hydrogel prepared via the sol-gel process from a hybrid collagen-inspired peptide is presented. Finally, the prospects opened up by the development of 3D printing are considered.
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Read the articleAUTHORS
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Cécile ECHALIER : Doctorate in chemistry, specializing in biomolecular engineering - D. at the Institut des Biomolécules Max Mousseron, UMR 5247, and the Institut Charles Gerhardt de Montpellier, UMR 5253 Université de Montpellier, CNRS, ENSCM, Montpellier, France – Currently a post-doc at the European Molecular Biology Laboratory, Heidelberg, Germany
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Ahmad MEHDI : Professor at the University of Montpellier - Institut Charles Gerhardt de Montpellier, UMR 5253 University of Montpellier, CNRS, ENSCM, Montpellier, France
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Jean MARTINEZ : Professor at the University of Montpellier - Institut des Biomolécules Max Mousseron, UMR 5247 Université de Montpellier, CNRS, ENSCM, Montpellier, France
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Gilles SUBRA : Professor at the University of Montpellier - Institut des Biomolécules Max Mousseron, UMR 5247 Université de Montpellier, CNRS, ENSCM, Montpellier, France
INTRODUCTION
Burns are the 2nd leading cause of accidental death in adults. Every year in France, nearly 400,000 people suffer burns, 10,000 of them requiring hospitalization, and 1,000 dying as a result. In addition, diabetes is diagnosed in 3 million French people. Repeated and prolonged hyperglycemia causes damage to nerves and blood vessels, leading to 10,000 foot and toe amputations every year. 85% of these amputations are due to non-healing foot ulcers. Finally, osteoarthritis is an osteoarticular disease that affects 10 million French people, and is characterized, among other things, by cartilage degradation. What burns, ulcers and osteoarthritis have in common is damaged tissue that struggles to regenerate. To help this tissue repair itself, or to replace it, we can use a physiologically compatible reconstructive material known as a biomaterial. Ideally, the biomaterial will interact with the cells, helping them to proliferate and guide them towards the development of new, healthy tissue. Collagen, as the major component of the extracellular matrix, is a precursor of choice for the preparation of biomaterials.
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KEYWORDS
tissue engineering | artificial extracellular matrix | regenerative medicine
Collagen-based biomaterials for health applications
Multiscale structure and biological role of collagen
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