Overview
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Read the articleAUTHORS
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Gautier LAURENT: Doctoral student - Institut UTINAM, UMR 6213 CNRS – University of Franche-Comté, Besançon, France
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Gloria JIMENEZ SANCHEZ: Doctoral student - Institut UTINAM, UMR 6213 CNRS – University of Franche-Comté, Besançon, France
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Rana BAZZI: Senior Lecturer - Institut UTINAM, UMR 6213 CNRS – University of Franche-Comté, Besançon, France
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François LUX: Senior Lecturer - Institut Lumière Matière, UMR 5306 CNRS – Université Lyon 1, Villeurbanne, France
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Pascal PERRIAT: Professor - Matériaux Ingénierie et Science, UMR 5510 CNRS – INSA Lyon, Villeurbanne, France
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Olivier TILLEMENT: Professor - Institut Lumière Matière, UMR 5306 CNRS – Université Lyon 1, Villeurbanne, France
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Stéphane ROUX: Professor - Institut UTINAM, UMR 6213 CNRS – University of Franche-Comté, Besançon, France
INTRODUCTION
Although they are non-biodegradable, gold nanoparticles are the focus of much research into their use as imaging and/or therapeutic agents. This keen interest in biomedical applications of gold nanoparticles is due to an original combination of properties that depend on their composition, size and shape. By reviewing the general context of nanoparticle development, the physico-bio-chemical constraints of solid tumors and the main properties of gold nanoparticles, this article reviews and analyzes the various strategies being explored for the design of imaging and/or therapeutic agents based on gold nanoparticles.
Owing to the original properties of gold nanoparticles which depend on their composition, their size and their shape, an intense research activity is focused on their application as contrast agents for imaging and/or therapeutic agents. This article identifies and analyzes different strategies explored for designing such agents and their potential for biomedical applications.
multifunctional nanoparticles, contrast agent, oncology, state of the art, multimodality, image-guided therapy, theranostics.
multifunctional nanoparticles, contrast agent, oncology, state of art, multimodality, image guided therapy, theranostics.
This article is a tribute to our colleague and friend Pascal PERRIAT, a brilliant pioneer in the development of nanoparticles for biomedical applications.
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KEYWORDS
multimodality | image guided therapy | theranostics | oncology | contrast agent
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Multifunctional gold nanoparticles for imaging and therapy
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