2. Qualitative methods for studying the relationship between structure and activity (RSA)
This approach is based on the following relationship :
in which biological activity is quantified as a function of the basic chemical structure, or pharmacophore, responsible for the biological activity and containing certain substituents. In the past, a pharmacophore was defined in terms of a static, often planar, molecular structure. Recent advances in chemistry and molecular modeling have made it possible to take into account its three-dimensional structure, as well as its dynamic properties, contributing to the improvement of SAR studies.
2.1 Structural analogues
Structural analogues are derivatives obtained by modifying the reference pharmacophore of an active ingredient. The latter is a natural or synthetic derivative. By modifying...
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Qualitative methods for studying the relationship between structure and activity (RSA)
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References
Books dealing with the structure and/or preparation, therapeutic indications of drugs or active ingredients:
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