3. Properties of ophthalmic forms

3.1 Sterility

The surface of the eye is contaminated by a number of micro-organisms. Bacterial composition is influenced by the flora of the skin adjacent to the eye and by the hygiene of the surrounding environment. However, the number and variety of germs present are reduced by the eye's various defense mechanisms. The eyelids and their blinking, as well as certain substances dissolved in the tear fluid, are involved in these mechanisms. However, contamination can occur during the administration or storage of ophthalmic forms. In...