2. How to identify and measure residual solvents?
2.1 General methods
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Weight loss
Historically, this was the first method to appear in pharmacopoeias. It can be performed either at atmospheric pressure or under reduced pressure. It is, of course, a very easy method to implement, particularly in the context of routine control, but it does have a number of disadvantages:
lack of specificity;
product consumer (1 to 2 g);
limit of quantification (LOQ) of around 0.1%;
atmospheric humidity may affect results.
With the development of thermogravimetric analysis (TGA), the detection limit has been improved (in...
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How to identify and measure residual solvents?
Setting up specifications
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