9. Use the profile to decide whether the method is valid
Currently, in the literature and in standards dealing with the accuracy profile, it is proposed to define as the validity range of the method the concentration range for which the limits of the dispersion intervals β- ID lie between the acceptability limits . This leads to the following conclusions for the example.
In the case of nicotinamide in milk, we can see that the upper limit of β-ID intersects the upper limit of acceptability at around 0.4 mg L - 1 (a finer calculation shows that the intersection is at 0.399 mg L - 1 ). Overall, below 0.4 mg L - 1 , the analyst can...
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Use the profile to decide whether the method is valid
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Bibliography
Collège Français de Métrologie: Application of the new VIM3 calibration concept (Reissued 2014)
Commission Decision of August 12, 2002 implementing Council Directive 96/23/EC as regards the performance of analytical methods and the interpretation of results (2002/657/EC)
Feinberg (M.), Labo-Stat: Guide de validation des méthodes d'analyse...
Normative references
ISO 16140: 2003 Microbiology of food: validation protocol for alternative methods (2003) ISO, Geneva
NF EN ISO/CEI 17025 : 2005 General requirements for the competence of testing and calibration laboratories (2005) ISO, Geneva
NF V03-110 (May 2010) Analysis of agricultural and food products – Characterization protocol for the validation of a quantitative analysis method...
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