Overview
ABSTRACT
Designing a microfluidic device involves to consider the properties of the materials, the management of fluids inside the microchannels, the hydrodynamics phenomenun set by channels’ geometry and the physical chemistry of fluids. After describing the physicochemical and hydrodynamic phenomena to know and tune in order to develop methods of sample processing, the different building blocks belonging to the microfluidics’ toolbox are presented to help the process designer to exploit these compounds in the wisest way.
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Read the articleAUTHORS
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Clarisse MARIET: Research engineer - Direction de l'Énergie Nucléaire (DEN), Service d'Études Analytiques et de Réactivité des Surfaces (SEARS), CEA, Université Paris-Saclay, Gif sur Yvette, France
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Laurent VIO: Research engineer - Direction de l'Énergie Nucléaire (DEN), Service d'Études Analytiques et de Réactivité des Surfaces (SEARS), CEA, Université Paris-Saclay, Gif sur Yvette, France
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Christine DALMAZZONE: Research engineer - Applied Physics, Chemistry and Mechanics Division, - IFP Énergies nouvelles (IFPEN), Rueil-Malmaison, France
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Marie MARSIGLIA: Research engineer - Applied Physics, Chemistry and Mechanics Division, - IFP Énergies nouvelles (IFPEN), Rueil-Malmaison, France
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Axel VANSTEENE: Doctoral student - Direction de l'Énergie Nucléaire (DEN), Service d'Études Analytiques et de Réactivité des Surfaces (SEARS), CEA, Université Paris-Saclay, Gif sur Yvette, France
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Emmanuel MIGNARD: Research Manager - CNRS, University of Bordeaux, Solvay, LOF, UMR 5258, Pessac, France
INTRODUCTION
The article
The choice of a microfluidic device for chemistry implies the prior consideration of certain constraints such as the choice of material(s) for device design and fluid management in the microchannels: chemical compatibility, preferential wettability at the walls, pressure drop, mixing and residence times, management of a solid fraction (integration of a fixed bed or flow of a suspension, for example), and so on. This article therefore focuses on describing the physico-chemical and hydrodynamic phenomena that need to be understood and mastered in order to develop sample treatment methods such as electrokinetic, chromatographic or liquid-liquid extraction techniques. Secondly, the various building blocks in the microfluidic systems toolbox will be presented, to help the process designer make the most judicious use of them. Examples of automated processes for the oil industry will be presented.
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KEYWORDS
isotachophoresis | liquid-liquid extraction | solid phase separation | segmented flow
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