7. ASTM D6355 test: human testing, standard test method for human repeat insult patch testing (HRIPT)
This test was developed in the United States and standardized by the ASTM to evaluate the sensitizing potential of a cosmetic preparation or medical device intended to remain in contact with the body.
The principle of the test is the same as in animal testing.
Induction: the study material is applied at relatively low or non-irritating doses for three weeks to the volunteer's back or arm.
The latency period is two weeks.
Triggering: a single application of a non-irritating dose is made over 48 hours.
Skin reaction rating: an examination and rating of erythema and edema are performed.
The Ultimate Scientific and Technical Reference
This article is included in
Chemical risk prevention manager
This offer includes:
Knowledge Base
Updated and enriched with articles validated by our scientific committees
Services
A set of exclusive tools to complement the resources
Practical Path
Operational and didactic, to guarantee the acquisition of transversal skills
Doc & Quiz
Interactive articles with quizzes, for constructive reading
ASTM D6355 test: human testing, standard test method for human repeat insult patch testing (HRIPT)
In vitro sensitization tests
Bibliography
A. Lombard et al. - Technical and economic evaluation of products in the early stages of development. Part 2, pp. 153-281, ISTE Publishing Ltd London (2024).
Websites
ECHA (European Chemical Agency)
The European Chemicals Agency implements EU chemicals legislation to protect human health and the environment. Its work also contributes to the smooth functioning of the internal market, innovation, and the competitiveness of the European chemical industry. Everything is made from chemicals. Improving knowledge of hazardous...
The Ultimate Scientific and Technical Reference
