2. How do you establish a VLEP?
2.1 Setting VLEP
Establishing ELVs is an important step in the overall process of assessing the hazards of a chemical substance. It is the logical outcome of the studies carried out to determine the ADME of the substance, as well as the results of short-, medium- and long-term "in vitro and in vivo" toxicological studies.
The first step is to establish the toxicological profile of the substance and collect all relevant data, then select the most relevant and valid studies (Klimisch).
Physicochemical data relevant to inhalation must be collected, in particular form (gas or particles), particle size, liquid volatility (boiling point and vapor pressure – PKa), solubility in aqueous and lipid media, and partition coefficient (log K o/w)....
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How do you establish a VLEP?
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Bibliography
Also in our database
Bibliography
ECETOC: Guidance on Assessment Factors to Derive a DNEL; Technical Report N°110, 2010.
ECHA: Guidance on information requirements and chemical safety assessment Chapter R.8: Characterisation of dose [concentration]-response for human health, version 2.1, 2012.
ECHA: How to prepare toxicological summaries in IUCLID and how to derive...
Websites
In particular, ECHA publishes a guide for characterizing concentrations in order to protect the health of exposed persons, and a guide for determining exposure to chemicals. These guides are published by ECHA, the European Chemicals Agency.
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