Overview
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Alain LOMBARD: Toxicologist and risk management consultant, Allotoxconsulting, Antibes, France
INTRODUCTION
Sensitization to a chemical substance occurs after repeated exposure to low doses over a period of time. Sensitization reactions (allergies) occur unexpectedly upon subsequent accidental exposure to the sensitizing substance.
Tests on laboratory animals follow the same pattern: induction –latency period– triggering, followed by the rating of effects.
It is also important to know how to use sensitization tests and be able to interpret the results of studies in order to recognize and evaluate the allergenic potential of a chemical substance for humans.
Official tests for detecting the sensitizing potential of a substance must therefore be chosen with care, and their results are important for the classification of the substance.
What tests are available and how should they be interpreted?
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Detecting sensitizing substances through animal and human testing
What tests can be used to detect sensitizing substances?
Bibliography
A. Lombard et al. - Technical and economic evaluation of products in the early stages of development. Part 2, pp. 153-281, ISTE Publishing Ltd London (2024).
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The European Chemicals Agency implements EU chemicals legislation to protect human health and the environment. Its work also contributes to the smooth functioning of the internal market, innovation, and the competitiveness of the European chemical industry. Everything is made from chemicals. Improving knowledge of hazardous...
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