4. Skin sensitization test: Local lymph node assay in mice, LLNA (Local Lymph Node Assay), OECD no. 429
The LLNA test is based on the principle that sensitizers induce lymphocyte proliferation in lymph nodes draining the site of test substance application. This proliferation is proportional to the dose applied and the potency of the allergen. This makes it easy to obtain a quantitative measure of sensitization.
4.1 Induction
Days 1, 2 and 3: apply 25 μl of a suitable dilution of test substance, vehicle alone or TP to the back of each ear.
SCROLL TO TOP4.2 Latency time
No treatment is...
Exclusive to subscribers. 97% yet to be discovered!
Already subscribed? Log in!
Skin sensitization test: Local lymph node assay in mice, LLNA (Local Lymph Node Assay), OECD no. 429
Test no. 442A: skin sensitization. Local lymph node stimulation test (DA)
Article included in this offer
"Safety and risk management"
(
459 articles
)
Updated and enriched with articles validated by our scientific committees
A set of exclusive tools to complement the resources
Exclusive to subscribers. 97% yet to be discovered!
Already subscribed? Log in!
