1. What tests can detect sensitizing substances?
1.1 Skin sensitization
Four skin sensitization tests in animals are described, including three validated regulatory tests, and two tests in humans. These tests are based on T-cell mediation.
Tests in albino guinea pigs are carried out as follows:
sensitization induction ;
latency/maturation time and cell proliferation (rest 10-15 days) ;
triggering ;
scoring of erythema and localized edema at the site of the triggering application using the grid. Results are compared between the control and treatment groups.
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What tests can detect sensitizing substances?
Magnusson and Kligman's Guinea Pig Maximization Test (M&K - OECD test no. 406: skin sensitization)
Websites
www.oecd.org OECD Guidelines for the Testing of Chemicals: these are a set of internationally-agreed test methods used by governments, industry and independent laboratories to determine the safety of chemicals and formulations, including pesticides and industrial chemicals. They cover tests on the physico-chemical properties of substances, their effects on human...
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