13. Frequently asked questions
How to choose between animal testing?
Generally, the GPMT is used for active ingredients and the Buehler test for formulations. The GPMT lasts about 23-25 days, the Buehler test about 30-32 days.
The GMPT is a maximization test, magnifying reactions in animals compared with humans. It sometimes gives false positives.
The Buehler test is closer to actual human exposure conditions. It is better suited to formulations and cosmetics, but can give false negatives.
For both tests, colorants cannot be evaluated. In addition, as with skin irritation tests, both require laboratories experienced in reading erythema and edema.
The LLNA test uses quantitative cell count or radioactivity measurements to assess the dose-response relationship. It therefore appears more reliable...
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Frequently asked questions
Abbreviations and acronyms
Websites
www.oecd.org OECD Guidelines for the Testing of Chemicals: these are a set of internationally-agreed test methods used by governments, industry and independent laboratories to determine the safety of chemicals and formulations, including pesticides and industrial chemicals. They cover tests on the physico-chemical properties of substances, their effects on human...
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