11. Frequently asked questions

What physico-chemical data do I need to know before starting an irritation/corrosion test?

The essential physico-chemical data to know before starting an irritation/corrosion test are :

• pH (acidic or basic) to determine the limit of "in vivo" and "in vitro" tests;

• solubility and stability of the substance in water and fats for penetration through the skin and mucous membranes, as well as respiratory impact (see Toxicology: Routes of penetration and bioavailability in the body (ADME) [FIC 1168]...